Greetings…
I am working on setting up in-house hard proofing. We run on Mac and I am looking for any advice on what I need to get this rolling.
Thanks much! 
That’s a pretty wide topic. You can search on these forums for the word “proofing” and look in the PrintForums and PressForums for some good information that has been posted already. That can get you started. Then you can come back here if you have specific questions that you want answered.